The Forensic Crash Unit is investigating a fatal, two vehicle traffic crash which occurred South of Esk earlier this morning.
Around 3.15am, a station wagon and a semi-trailer collided on the Brisbane Valley Highway at Hamon Cove.
The male driver of the car was pronounced deceased at the scene.
The male driver of the truck sustained minor injuries and was transported to Ipswich Hospital.
The Highway is expected to remain closed in both directions until approximately midday today.
If you have information for police, contact Policelink on 131 444 or provide information using the online form 24hrs per day.
You can report information about crime anonymously to Crime Stoppers, a registered charity and community volunteer organisation, by calling 1800 333 000 or via crimestoppersqld.com.au 24hrs per day.